Valve Series
SoloCheck™
Single-use non-return valve engineered for reliable one-way flow control and passive backflow prevention in high-purity bioprocessing systems. No springs. No metal. No complex mechanisms.
Single-use non-return valve engineered for reliable one-way flow control and passive backflow prevention in high-purity bioprocessing systems. No springs. No metal. No complex mechanisms.
An innovative diaphragm-based mechanism delivers a clean, straight-through flow path — gentle enough for fragile biologics, reliable enough for continuous processing.
Opens gently to minimize shear stress and pressure spikes. Protects fragile biologics, viral vectors, and living cells from mechanical damage at the point of flow initiation.
Straight-through flow path maintains excellent flow efficiency. Reduces system resistance and supports gentle handling of high-value products.
Prevents backflow, contamination, and cross-contamination. Protects upstream filters, pumps, chromatography columns, and critical process components.
Fully compatible with standard gamma sterilisation protocols up to 50 kGy. No material degradation or performance change.
Exceptional extractables profile. USP Class VI, FDA compliant, BSE/TSE free. Supports product purity and regulatory compliance.
Reduces hold-up volume. No dead legs, no entrapment zones, no product loss to system geometry. Simplifies cleaning validation.
Polypropylene body with TPE elastomer diaphragm. Resistant to bioprocess buffers, media, acids, bases, and sanitising agents.
Inline design — 1" HB to 1" HB, optional 2" Tri-Clamp. Easy to integrate into tubing sets, manifolds, and space-constrained assemblies.
No external actuation, no power, no control signal. Reduces system complexity and eliminates a potential failure point.
| Parameter | SoloCheck™ | Stainless Steel Check Valve |
|---|---|---|
| Mechanism | Diaphragm — no springs, no metal | Spring-loaded ball or disc |
| Cracking pressure | Very low — gentle start-up | Higher — spring resistance |
| Pressure drop | Minimal — straight-through path | Higher — tortuous flow around ball/disc |
| Hold-up volume | Ultra-low — inline design | Higher — cavity around sealing element |
| Cleaning | None — single-use, dispose after run | CIP/SIP, disassembly, inspection |
| Validation | Pre-validated, gamma sterilised | Cleaning validation, re-sterilisation records |
| Extractables | Ultra-pure — USP Class VI | Metal leachables possible over time |
| Metal-free | Yes — no springs, no metal contact | No — spring, ball/disc, housing all metal |
| Turnaround | Replace in seconds | Disassemble, clean, inspect, reassemble, sterilise |
Prevents suck-back on pump stop. Protects product from reverse flow when PIXER® or other pumps cycle off.
Protects upstream membranes and filters from reverse pressure during TFF, depth filtration, and sterile filtration.
Prevents backflow into columns during buffer switching, gradient formation, and fraction collection.
One-way flow assurance in buffer delivery lines, media feed systems, and multi-path manifold assemblies.
Continuous flow protection in perfusion bioreactor setups where backflow risks contamination or cell damage.
Prevents cross-contamination in critical downstream steps where product purity and sterility are non-negotiable.
SoloCheck™ integrates directly with PIXER® pumps, VannX™ valves, and Vannefold™ manifolds — providing complete single-use flow control from pump to process without stainless steel, without springs, and without compressed air.
Available as a standalone component or integrated into bespoke single-use fluid path assemblies.