Who we are
A bioprocessing solutions provider in precision fluid handling. We design the pumps, valves and complete systems, with control from our sister company ConSynSys, that let manufacturers process the biologics conventional equipment cannot.
“Bioprocess failures are more often mechanical than chemical.”Michael Gagne, Founder
Our story
Alphinity was founded by Michael Gagne on a simple observation: bioprocess failures are more often mechanical than chemical. Product loss, batch variability, and scale-up failure are rarely caused by bad science. They're caused by equipment that was never designed for the fluids it's asked to handle.
We integrate Aquasyn's 30+ years of valve manufacturing heritage with new pump technology (the PIXER® single-use radial diaphragm pump) and cloud-native automation through ConSynSys™. The result is a complete precision fluid handling platform, purpose-built for bioprocessing from the ground up.
Every component we make exists because the existing options were failing. Roller pumps that destroy product. Pneumatic valves that can't hold pressure. Automation platforms that can't talk to each other. We built what the industry needed, and what nobody else was willing to build.
Our team brings deep experience across biopharmaceutical manufacturing, process development, mechanical engineering, automation, and regulatory compliance. We understand the science, the engineering, and the regulatory landscape, because we've worked in all three.
Alphinity operates from two locations: Carson City, Nevada (our US headquarters for system integration, customer engineering, and commercial operations) and Jüri, Estonia (our European center for precision manufacturing and R&D).
Two continents, one engineering culture. Every pump, valve, and system meets the same standard, whether it ships from Nevada or Estonia.
The problem
New modalities are failing in manufacturing, not because the science is wrong, but because the equipment was built for water and chemicals, not sensitive biologics.
Roller pumps compress fragile product on every revolution.
Negative inlet pressure damages product invisibly.
Pressure spikes destabilize TMP, flux and sensor data.
Conventional pumps struggle with viscous fluids.
Different equipment at each scale breaks continuity.
Equipment variability stretches qualification timelines.
Our approach
We don't sell components and hope they work. We start with the process: understanding the fluid, the pressures, the sensitivities. Then we engineer equipment that maintains those conditions from bench to clinical manufacturing.
Ultra-low shear diaphragm pumps, proportional control valves, and gravity-flooded architectures. Every component engineered to protect your product, not just move it.
Single-use flowpaths, PIXER® pumps, VannX™ valves, and ConSynSys™ automation. Designed as a unified platform, not assembled from incompatible parts.
Same architecture from 30 mL screening to 10 L clinical batches. Same pumps, same valves, same control logic. Your process doesn't change when the scale does.
ConSynSys™ cloud-native control with 21 CFR Part 11 architecture. Recipe management, data logging, and closed-loop control, built in from day one, not bolted on.
Our heritage
Alphinity was founded in 2021. The know-how behind it goes back much further: decades of hygienic valves, single-use systems and patented engineering, built by the same people who lead the company today.
Every stainless valve body starts as solid 316L bar. Machined on 5-axis CNC, welded, polished, then polished again so the weld matches the metal either side, and inspected by the people who made it.
Decades of drawings, from a single sample valve to multi-port block bodies, manifolds and complete skids. Every design is approved by the customer before anything is cut.
Our founder and engineers are named inventors on patents covering valve assemblies, integrated pumps and the PIXER® pump architecture. Our bag technology adds five granted patents.
Garry Gagne founds Alpha Stainless, renamed Alpha Bio in 2001, supplying and building stainless process equipment for California's early biotech manufacturers: welding, polishing, electropolishing and complete systems. Michael Gagne joins in 1989 and learns the industry on the shop floor.
Where it startedMichael Gagne founds Aquasyn to build the hygienic valves bioprocessing could not buy. Bodies machined from solid 316L bar, and engineered designs such as the Valbow® right-angle sample valve and Tork-Tite® Feet, set the standard the group still builds to.
CraftsmanshipMichael files the patent behind ARTeSYN's pinch valve technology, the start of the group's move from stainless into single-use.
InnovationAquasyn sample valves and glass sampling bottles are featured in "The Birth of Biotech" exhibit at the Smithsonian's National Museum of American History in Washington, D.C., from 2013 to 2014.
National recognitionARTeSYN brings automated pinch valves, molded single-use flow paths and process systems into biopharmaceutical manufacturing, with engineering and manufacturing in Estonia. Michael Gagne, Dean Richards and Steven Cates co-invent its foundational valve assembly.
EngineeringThe Northern Nevada Development Authority awards Aquasyn the Silver Forge Award for innovative manufacturing leadership. The same year, the integrated pump patent behind PIXER® is filed.
Manufacturing excellenceThe pinch valves and single-use systems the team built become part of one of the industry's leading bioprocessing companies.
The same team starts again with what comes next: the PIXER® pump, electric single-use valves, single-use bags and a PC-based process control platform, designed as one system for the medicines conventional equipment was never meant to handle.
The TFFi™ single-use TFF system wins Best Technology Innovation at the Interphex Exhibitor Awards in New York. Aquasyn turns 30, and Alpha Bio turns 40.
Michael Gagne has spent more than 40 years in bioprocess fluid handling. He founded Aquasyn in 1996 to build the valves the industry could not buy, then co-founded ARTeSYN Biosolutions, whose pinch valves and single-use systems were adopted across biopharmaceutical manufacturing before Repligen acquired the company in 2020.
He founded Alphinity and sister company ConSynSys in 2021 to build what comes next: pumps, valves and systems designed for the medicines conventional equipment was never meant to handle. He is a named inventor on more than 20 granted patents in the US, Europe and Asia, with more pending, covering valve assemblies, integrated pumps, fluid preparation and the PIXER® pump architecture. His mission, and the company's, is Enabling Abundance in Medicine™.
Dean has designed and built bioprocess valves for more than 30 years. He spent nearly a decade as a senior design engineer at one of Europe's leading diaphragm valve manufacturers, taking products from 3D design and stress simulation through verification testing and on-site customer support. He joined Aquasyn in 2002 as Engineering Manager, then ran its operations, and as General Manager and now Managing Member has led the company for more than 15 years. In 2014 he co-founded ARTeSYN Biosolutions as Chief Operating Officer, scaling manufacturing across Ireland and Estonia, and after its 2020 acquisition served as Vice President of Operations, integrating the business into a global bioprocessing company. He is a co-inventor of ARTeSYN's foundational valve assembly.
Steven has worked in bioprocessing for more than 40 years. He spent nearly two decades in engineering, product development and technical services for a global filtration company in the US and Germany, helping develop early TFF holders and cassettes and supporting some of the first biotech manufacturing plants. As VP of Engineering and Systems at Alpha Bio for 16 years, he led system design, controls and automation, field service and single-use instrumentation, delivering systems for viral filtration, TFF, gradient chromatography and inline dilution. He built the systems that first proved ARTeSYN's pinch valves in production and is a co-inventor of its foundational valve assembly. He holds an MSc in Biological Sciences from Stanford and a BSc in Electrical Engineering.
Chris has worked on every side of bioprocessing for 20 years. He started on the manufacturing floor, running chromatography and ultrafiltration for clinical batches and becoming the site expert in both, then moved into validation, tech transfer and MSAT for biologics and viral vector manufacturers. As a senior process engineer and project manager at two global bioprocess equipment companies, he designed and delivered systems for customers worldwide. Along the way he packed chromatography columns up to 1,600 mm and helped develop an industry-first 2,000 L irradiated bag with integral mixing. He now leads process development and applications at Alphinity, and is the technical lead behind the award-winning TFFi™.
Where we are
United States | Headquarters
2144 College Parkway, Suite 140
Carson City, Nevada 89706
United States
+1 (775) 255-0707
Estonia | Manufacturing & R&D
Ringi tee 13, Jüri, 75301
Harju maakond
Estonia
Our partners
Alphinity works alongside three affiliated organizations to deliver complete precision fluid handling solutions for bioprocessing.
Over 30 years of valve manufacturing heritage. Aquasyn's expertise in bioprocess valve design and manufacturing forms the foundation of the VannX™ valve platform and Alphinity's fluid path engineering.
Cloud-native bioprocess automation. ConSynSys™ delivers recipe management, closed-loop control, data logging, and 21 CFR Part 11 architecture: the intelligence layer that ties every Alphinity system together.
Where the group began. Founded in 1986 as Alpha Stainless, Alpha Bio has supplied process equipment to biopharmaceutical manufacturers for 40 years, and today distributes the group's products and partner lines with local stock and support.
Industry Associations
Alphinity is an active member of the bioprocessing industry's leading professional associations.
Common questions
Alphinity is a bioprocessing technology company specializing in precision fluid handling. We design single-use diaphragm pumps (PIXER), electric diaphragm valves (VannX), tangential flow filtration systems (TFFi), and bespoke integrated systems for biopharmaceutical manufacturing, with cloud-native automation from our sister company ConSynSys.
Alphinity was founded in 2021 by Michael Gagne, its Founder and CXO. He previously founded Aquasyn in 1996 and co-founded ARTeSYN Biosolutions, which Repligen acquired in 2020.
Alphinity operates from two locations: Alphinity USA, Inc. at 2144 College Parkway, Suite 140, Carson City, Nevada 89706, USA; and Alphinity OÜ at Ringi tee 13, Jüri, 75301, Harju maakond, Estonia.
Aquasyn is an affiliated organization with over 30 years of valve manufacturing heritage, founded by Michael Gagne in 1996. Alphinity integrates Aquasyn's valve expertise with new pump technology (PIXER) and cloud-native automation (ConSynSys) to deliver complete precision fluid handling solutions for bioprocessing.
Get in Touch
Whether you need a single component or a complete system, the conversation starts with your process.