About Alphinity
Alphinity is a bioprocessing technology company specializing in precision fluid handling. We design pumps, valves, and integrated systems, with control from our sister company ConSynSys, that enable manufacturers to process sensitive biologics that conventional equipment cannot support.
Our story
Alphinity was founded by Michael Gagne on a simple observation: bioprocess failures are more often mechanical than chemical. Product loss, batch variability, and scale-up failure are rarely caused by bad science. They're caused by equipment that was never designed for the fluids it's asked to handle.
We integrate Aquasyn's 30+ years of valve manufacturing heritage with new pump technology (the PIXER® single-use radial diaphragm pump) and cloud-native automation through ConSynSys™. The result is a complete precision fluid handling platform, purpose-built for bioprocessing from the ground up.
Every component we make exists because the existing options were failing. Roller pumps that destroy product. Pneumatic valves that can't hold pressure. Automation platforms that can't talk to each other. We built what the industry needed, and what nobody else was willing to build.
Our team brings deep experience across biopharmaceutical manufacturing, process development, mechanical engineering, automation, and regulatory compliance. We understand the science, the engineering, and the regulatory landscape, because we've worked in all three.
Alphinity operates from two locations: Carson City, Nevada (our US headquarters for system integration, customer engineering, and commercial operations) and Jüri, Estonia (our European center for precision manufacturing and R&D).
Two continents, one engineering culture. Every pump, valve, and system meets the same standard, whether it ships from Nevada or Estonia.
Leadership
Founder & CXO
Michael Gagne has spent more than 40 years in bioprocess fluid handling. He founded Aquasyn in 1996 to build the valves the industry could not buy, then co-founded ARTeSYN Biosolutions, whose single-use valves and systems were adopted across biopharmaceutical manufacturing before Repligen acquired the company in 2020.
He founded Alphinity in 2021 to build what comes next: pumps, valves, and systems designed for the medicines conventional equipment was never meant to handle. He also founded sister company ConSynSys in 2021, which provides the control layer for Alphinity's hardware. He is a named inventor on patents covering single-use valves, integrated pumps, and the PIXER® pump architecture. His mission, and the company's, is Enabling Abundance in Medicine™.
The problem
New modalities (viral vectors, cell therapies, mRNA, LNPs) are failing in manufacturing. Not because the science is wrong, but because the equipment was designed for water and chemical transfer, not sensitive biologics. The industry is trying to manufacture 21st-century medicines with 20th-century fluid handling.
Roller-based pumps compress product every revolution, destroying fragile viral vectors, exosomes, and cell-based therapies through repeated mechanical stress.
Negative inlet pressure creates microbubble collapse: an invisible source of product damage that's difficult to detect and impossible to reverse.
Pressure transients destabilize transmembrane pressure and inline sensors, leading to inconsistent flux, fouled membranes, and unreliable process data.
Conventional pumps fail above ~500 cP. High-concentration mAbs, dense buffers, and viscous intermediates simply cannot be processed reliably.
Different equipment at each scale breaks process continuity. What works at bench fails in manufacturing because the mechanical conditions change.
Unstable processes extend qualification timelines. When equipment introduces variability, every batch becomes a question mark, and regulators notice.
Our approach
We don't sell components and hope they work. We start with the process: understanding the fluid, the pressures, the sensitivities. Then we engineer equipment that maintains those conditions from bench to clinical manufacturing.
Ultra-low shear diaphragm pumps, proportional control valves, and gravity-flooded architectures. Every component engineered to protect your product, not just move it.
Single-use flowpaths, PIXER® pumps, VannX™ valves, and ConSynSys™ automation. Designed as a unified platform, not assembled from incompatible parts.
Same architecture from 30 mL screening to 10 L clinical batches. Same pumps, same valves, same control logic. Your process doesn't change when the scale does.
ConSynSys™ cloud-native control with 21 CFR Part 11 architecture. Recipe management, data logging, and closed-loop control, built in from day one, not bolted on.
Where we are
United States | Headquarters
2144 College Parkway, Suite 140
Carson City, Nevada 89706
United States
+1 (775) 255-0707
Estonia | Manufacturing & R&D
Ringi tee 13, Jüri, 75301
Harju maakond
Estonia
Our partners
Alphinity works alongside two affiliated organizations to deliver complete precision fluid handling solutions for bioprocessing.
Over 30 years of valve manufacturing heritage. Aquasyn's expertise in bioprocess valve design and manufacturing forms the foundation of the VannX™ valve platform and Alphinity's fluid path engineering.
Cloud-native bioprocess automation. ConSynSys™ delivers recipe management, closed-loop control, data logging, and 21 CFR Part 11 architecture: the intelligence layer that ties every Alphinity system together.
Industry Associations
Alphinity is an active member of the bioprocessing industry's leading professional associations.
Common questions
Alphinity is a bioprocessing technology company specializing in precision fluid handling. We design single-use diaphragm pumps (PIXER), electric diaphragm valves (VannX), tangential flow filtration systems (TFFi), and bespoke integrated systems for biopharmaceutical manufacturing, with cloud-native automation from our sister company ConSynSys.
Alphinity was founded in 2021 by Michael Gagne, its Founder and CXO. He previously founded Aquasyn in 1996 and co-founded ARTeSYN Biosolutions, which Repligen acquired in 2020.
Alphinity operates from two locations: Alphinity USA, Inc. at 2144 College Parkway, Suite 140, Carson City, Nevada 89706, USA; and Alphinity OÜ at Ringi tee 13, Jüri, 75301, Harju maakond, Estonia.
Aquasyn is an affiliated organization with over 30 years of valve manufacturing heritage, founded by Michael Gagne in 1996. Alphinity integrates Aquasyn's valve expertise with new pump technology (PIXER) and cloud-native automation (ConSynSys) to deliver complete precision fluid handling solutions for bioprocessing.
Get in Touch
Whether you need a single component or a complete system, the conversation starts with your process.